CD276 Protein (CD276) (His tag)

Produktnummer ABIN7194787

Dieses Recombinant CD276-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD276 Protein (CD276) (His tag) (ABIN7194787)

Target: CD276

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 98 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD276 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human B7-H3/CD276 Protein (His Tag)

Sequenz: Met 1-Thr 461

Produktmerkmale: A DNA sequence encoding the human CD276 (Q5ZPR3-1) extracellular domain (Met 1-Thr 461) was expressed, with a polyhistidine tag at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: CD276

Andere Bezeichnung: B7-H3/CD276

Hintergrund: B7 homolog 3,B7-H3,B7H34Ig-B7-H3,CD276,CD276 antigen,CD276 Molecule,Costimulatory molecule,B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

Molekulargewicht:

Calculated MW: 48.0 kDa

Observed MW: 73 kDa

Gen-ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints