Cathepsin S Protein (CTSS) (His tag)

Produktnummer ABIN7320704

Dieses Recombinant Cathepsin S-Protein wird in Human Cells exprimiert.

Kurzübersicht für Cathepsin S Protein (CTSS) (His tag) (ABIN7320704)

Target: Cathepsin S (CTSS)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 95 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Cathepsin S Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Cathepsin S/CTSS Protein (His Tag)

Sequenz: Val18-Ile340

Produktmerkmale: Recombinant Mouse Cathepsin S is produced by our Mammalian expression system and the target gene encoding Val18-Ile340 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Cathepsin S (CTSS)

Andere Bezeichnung: Cathepsin S/CTSS

Hintergrund:

Background: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer's disease (AD) and Down Syndrome (DS).

Synonym: Cathepsin S, CTSS

Molekulargewicht: 37.5 kDa

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades