BDNF Protein (AA 19-247)

Produktnummer ABIN7319494

Recombinant BDNF-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für BDNF Protein (AA 19-247) (ABIN7319494)

Target: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 19-247

Verwendungszweck: Recombinant Human BDNF Protein (with pro peptide)

Sequenz: Ala19-Arg247(R125A,R127A,R128A)

Produktmerkmale: Recombinant Human BDNF is produced by our E.coli expression system and the target gene encoding Ala19-Arg247 is expressed.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB, 10 % Trehalose, 100 mM NaCl, 0.02 % Tween 80, pH 6.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Andere Bezeichnung: BDNF

Hintergrund: Abrineurin,BDNF,Brain-Derived Neurotrophic Factor,The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

Molekulargewicht:

Calculated MW: 25.6 kDa

Observed MW: 28 kDa

Gen-ID: 627

UniProt: P23560

Pathways: RTK Signalweg, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity