APEX1 Protein
Kurzübersicht für APEX1 Protein (ABIN7318176)
Target
Alle APEX1 Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Verwendungszweck
- Recombinant Human APE1/APE Protein
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Sequenz
- Pro2-Leu318
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Produktmerkmale
- Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
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Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
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Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (GST tag)
APEX1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 97-195) protein (His-IF2DI Tag)APEX1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (His tag)APEX1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (T7 tag)APEX1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90% by SDS-PAGE SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 1) proteinAPEX1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 32-318) protein (His tag)APEX1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50 % Glycerol, pH 7.4.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Andere Bezeichnung
- APE1/APE
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Hintergrund
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Background: Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Synonym: DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
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Molekulargewicht
- 35.6 kDa
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UniProt
- P27695
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Pathways
- DNA Reparatur, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
Target
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