IL17C Protein (His tag)

Produktnummer ABIN7194048

Dieses Recombinant IL17C-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für IL17C Protein (His tag) (ABIN7194048)

Target: IL17C (Interleukin 17C (IL17C))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: >95 % as determined by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses IL17C Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse IL-17C Protein, His Tag

Sequenz: Asp 17 - Gln 194

Produktmerkmale: Mouse IL-17C, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 17 - Gln 194 (Accession # Q8K4C5-1).

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 25-27 kDa under reducing (R) condition due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, 0.5 M Arginine, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Antigendetails

Target: IL17C (Interleukin 17C (IL17C))

Andere Bezeichnung: IL-17C

Hintergrund: Synonyms: IL-17C,Cytokine CX2,IL17C,
Description: Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.

Molekulargewicht: 21.7 kDa

NCBI Accession: NP_665833

Pathways: Cellular Response to Molecule of Bacterial Origin