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SARS-CoV-2 Spike S1 Protein (His tag)

Recombinant SARS-CoV-2 Spike S1-Protein exprimiert in HEK-293 Cells und wurde in 9+ Publikationen erwähnt.
Produktnummer ABIN6952427

Kurzübersicht für SARS-CoV-2 Spike S1 Protein (His tag) (ABIN6952427)

Target

Alle SARS-CoV-2 Spike S1 Proteine anzeigen
SARS-CoV-2 Spike S1

Protein-Typ

Recombinant

Spezies

  • 97
  • 6
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
SARS Coronavirus-2 (SARS-CoV-2)

Quelle

  • 95
  • 3
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Applikation

SDS-PAGE (SDS), Functional Studies (Func)

Reinheit

>90 % as determined by SDS-PAGE.
  • Aufreinigungstag / Konjugat

    Dieses SARS-CoV-2 Spike S1 Protein ist gelabelt mit His tag.

    Sequenz

    AA 16-685

    Produktmerkmale

    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.9 kDa. The protein migrates as 100-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    AA 16-685

    Endotoxin-Niveau

    Less than 1.0 EU per μg by the LAL method.

    Biological Activity Comment

    Immobilized 2019-nCoV S1 protein, His Tag at 2 μg/mL (100 μL/well) can bind Human ACE2, Fc Tag with a linear range of 2-20 ng/mL (QC tested).
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handhabung

    Please avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C
  • Fan, Parr, Kang, Gupta: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." in: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).

    Lucas, Klein, Sundaram, Liu, Wong, Silva, Mao, Oh, Mohanty, Huang, Tokuyama, Lu, Venkataraman, Park, Israelow, Vogels, Muenker, Chang, Casanovas-Massana, Moore, Zell, Fournier, Wyllie, Campbell, Lee et al.: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." in: Nature medicine, (2021) (PubMed).

    Song, Bartley, Chow, Ngo, Jiang, Zamecnik, Dandekar, Loudermilk, Dai, Liu, Sunshine, Liu, Wu, Hawes, Alvarenga, Huynh, McAlpine, Rahman, Geng, Chiarella, Goldman-Israelow, Vogels, Grubaugh et al.: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." in: Cell reports. Medicine, pp. 100288, (2021) (PubMed).

    Maritz, Woudberg, Bennett, Soares, Lapierre, Devine, Kimberg, Bouic: "Validation of high-throughput, semiquantitative solid phase SARS coronavirus-2 serology assays in serum and dried blood spot matrices." in: Bioanalysis, (2021) (PubMed).

    Mazzini, Martinuzzi, Hyseni, Benincasa, Molesti, Casa, Lapini, Piu, Trombetta, Marchi, Razzano, Manenti, Montomoli: "Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples." in: Journal of immunological methods, Vol. 489, pp. 112937, (2021) (PubMed).

    Haslwanter, Dieterle, Wec, OBrien, Sakharkar, Florez, Tong, Rappazzo, Lasso, Vergnolle, Wirchnianski, Bortz, Laudermilch, Fels, Mengotto, Malonis, Georgiev, Quiroz, Wrapp, Wang, Dye, Barnhill, Dye et al.: "A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants. ..." in: mBio, Vol. 12, Issue 5, pp. e0247321, (2021) (PubMed).

    Pierce, Preston-Hurlburt, Dai, Aschner, Cheshenko, Galen, Garforth, Herrera, Jangra, Morano, Orner, Sy, Chandran, Dziura, Almo, Ring, Keller, Herold, Herold: "Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients." in: Science translational medicine, Vol. 12, Issue 564, (2020) (PubMed).

    Luetkens, Metcalf, Planelles, Zheng, Larragoite, Spivak, Spivak, Steinbach, Blaylock, Avila, Hankey, Martins, Slev, Mannuel, Sajadi, Rapoport, Atanackovic: "Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19." in: Blood advances, Vol. 4, Issue 19, pp. 4864-4868, (2020) (PubMed).

    Wei, Wan, Yan, Wang, Zhang, Yang, Zhang, Fan, Li, Deng, Sun, Gong, Yang, Wang, Wang, Li, Yang, Li, Zhang, Wang, Du, Zong, Yin, Zhang, Wang, Peng, Lin, Feng, Qin, Chen, Gao, Zhang, Cao, Zhong: "HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry." in: Nature metabolism, Vol. 2, Issue 12, pp. 1391-1400, (2020) (PubMed).

  • Target

    SARS-CoV-2 Spike S1

    Substanzklasse

    Viral Protein

    Hintergrund

    It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

    Molekulargewicht

    76.9 kDa

    Gen-ID

    43740568

    UniProt

    P0DTC2
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