CCL4 Protein (AA 24-92)

Produktnummer ABIN6952197

Produktdetails

Target: CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 24-92

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Cell Migration Assay (CMA)

Sequenz: APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN

Produktmerkmale: Recombinant Human CCL4 (MIP-1beta)

Endotoxin-Niveau: <0.01 EU per 1μg of the protein by the LAL method

Biological Activity Comment: EC50 = 0.23 nM determined by Calcium Flux

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: 12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution.

Haltbarkeit: 12 months

Antigendetails

Target: CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))

Andere Bezeichnung: CCL4 (MIP-1beta) (CCL4 Produkte)

Hintergrund: Monokine with inflammatory and chemokinetic properties binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Molekulargewicht: 7.818 kDa

UniProt: P13236