CCL3 Protein (AA 24-92)

Produktnummer ABIN6952188

Dieses Recombinant CCL3-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für CCL3 Protein (AA 24-92) (ABIN6952188)

Target: CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Cell Migration Assay (CMA)

Reinheit: > 97 % by SDS PAGE

Produktdetails

Proteineigenschaft: AA 24-92

Sequenz: SLAADTPTAC CFSYTSRQIP QNFIADYFET SSQCSKPGVI FLTKRSRQVC ADPSEEWVQK YVSDLELSA

Produktmerkmale: Recombinant Human CCL3 (MIP-1alpha)

Endotoxin-Niveau: <0.01 EU per 1μg of the protein by the LAL method

Biological Activity Comment: EC50 = 0.2 nM determined by Migration Assay in cells expressing recombinant CCR5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: 12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution.

Haltbarkeit: 12 months

Antigendetails

Target: CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))

Andere Bezeichnung: CCL3 (MIP-1alpha)

Hintergrund: Macrophage inflammatory proteins 1-alpha (MIP1alpha)(CCL3) binds to cell surface receptors CCR1 and CCR5. It is proinflammatory, leading to chemotaxis and activation of immune cells. It also inhibits proliferation of hematopoietic stem cells. Moreover, by binding to one of the HIV coreceptors, CCR5, it suppresses HIV infection.

Molekulargewicht: 7.716 kDa

UniProt: P10147

Pathways: Cellular Response to Molecule of Bacterial Origin, Autophagie