CCL2 Protein (AA 24-99)
Kurzübersicht für CCL2 Protein (AA 24-99) (ABIN6952165)
Target
Alle CCL2 Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- AA 24-99
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Sequenz
- QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSIDHLDKQ TQTPKT
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Produktmerkmale
- Recombinant Human CCL2 (MCP-1)
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Endotoxin-Niveau
- <0.01 EU per 1μg of the protein by the LAL method
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Biological Activity Comment
- EC50 = 0.067nM determined by Migration Assay of recombinant CCR2 containing cells
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Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) protein (His-Avi Tag,Biotin)
CCL2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) protein (His-Avi Tag)CCL2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) protein (His tag)CCL2 Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) protein (Fc Tag)CCL2 Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-99) (Active) protein (Biotin)CCL2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 97 % by SDS PAGE CMA, FACS Active
Chemokine (C-C Motif) Ligand 2 (CCL2) protein (His tag)CCL2 Spezies: Maus Wirt: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 1-99) protein (GST tag)CCL2 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Chemokine (C-C Motif) Ligand 2 (CCL2) (AA 24-96), (partial) protein (His tag)CCL2 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA
Chemokine (C-C Motif) Ligand 2 (CCL2) proteinCCL2 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
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12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution. -
Haltbarkeit
- 12 months
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- CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
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Andere Bezeichnung
- CCL2 (MCP-1)
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Hintergrund
- Monocyte chemoattractant protein-1 (MCP-1) (CCL2) is produced by many cell types at sites of inflammation. It regulates chemotaxis and transendothielial migration of monocytes, as well as memory T cells and natural killer cells by interacting with their membrane surface receptor CCR2. MCP-1 has also been implicated in a number of disease states, such as rheumatoid arthritis, psoriasis, atherosclerosis, autoimmune diseases, tumor progression, and HIV infection. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It binds to chemokine receptors CCR2 and CCR4.
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Molekulargewicht
- 8.662 kDa
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UniProt
- P13500
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion
Target
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