IFNA2 Protein (AA 24-188)

Produktnummer ABIN667040

Dieses Recombinant IFNA2-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für IFNA2 Protein (AA 24-188) (ABIN667040)

Target: IFNA2 (Interferon, alpha 2 (IFNA2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS), Activity Assay (AcA)

Reinheit: > 95 %

Produktdetails

Proteineigenschaft: AA 24-188

Sequenz: MCDLPQTHSL GSRRTLMLLA QMRRISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE

Produktmerkmale: Interferon alpha-2b (24-188) Human, Recombinant, E.coli

Aufreinigung: > 95% by SDS-PAGE

Endotoxin-Niveau: < 1 EU per 1ug of protein (determined by LAL method)

Biological Activity Comment: Measured by its binding ability in a functional ELISA with Human IFN-alpha/beta R2 (CAT# ATGP3952) in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4), 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: IFNA2 (Interferon, alpha 2 (IFNA2))

Andere Bezeichnung: IFN-alpha 2/IFNA2

Hintergrund: Interferon induces a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. Interferon alpha-2b can either inhibit or enhance immune cell activity within the tightly regulated microenvironment of inflammation, depending upon the concentration of the cytokine and the activation stage of the cell. Interferon alpha-2b was expressed in E. coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Molekulargewicht: 19.4 kDa (166aa) confirmed by MALDI-TOF

NCBI Accession: NP_000596

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Hepatitis C