GM-CSF Protein

Produktnummer ABIN935389

Recombinant GM-CSF-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für GM-CSF Protein (ABIN935389)

Target: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 98 % pure

Produktdetails

Sequenz: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK

Produktmerkmale: Purified recombinant Human GM-CSF protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of Mouse FDC-P1 cells is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7 units/mg.

Endotoxin-Niveau: < 0.1 ng per μg (1 EU/μg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Kommentare:

Biological activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of Mouse FDC-P1 cells is approx. 0.05 ng/mL, corresponding to a specific activity of approx. 2 x 10^7 units/mg.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with distilled water to a concentration of 0.1-1.0 mg/mL.

Buffer: Lyophilized from 10 mM HoAc.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Antigendetails

Target: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Andere Bezeichnung: GM-CSF

Hintergrund: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and Mouse molecules are species-specific and exhibit no cross-species reactivity.
Alternative Names: CSF-2 protein, MGI-1GM protein, Granulocyte/Macrophage Colony-Stimulating Factor protein, pluripoietin-alpha protein, GM-CSF protein

Molekulargewicht: 14.2 kDa

Pathways: JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin