alpha 2 Macroglobulin Protein (AA 620-750, partial) (His tag)

Produktnummer ABIN5713188

Dieses Recombinant alpha 2 Macroglobulin-Protein wird in Hefe produziert.

Kurzübersicht für alpha 2 Macroglobulin Protein (AA 620-750, partial) (His tag) (ABIN5713188)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: Hefe

Applikation: SDS-PAGE (SDS)

Reinheit: > 90 %

Produktdetails

Proteineigenschaft: AA 620-750, partial

Aufreinigungstag / Konjugat: Dieses alpha 2 Macroglobulin Protein ist gelabelt mit His tag.

Sequenz: LIYDLLPVKD LTGFPQGADQ REEDTNGCVK QNDTYINGIL YSPVQNTNEE DMYGFLKDMG LKVFTNSNIR KPKVCERLRD NKGIPAAYHL VSQSHMDAFL ESSESPTETR RSYFPETWIW DLVVVDSAGV A

Aufreinigung: SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Andere Bezeichnung: A2MG

Hintergrund: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Molekulargewicht: 16.9 kDa

UniProt: P06238

Pathways: Lipid Metabolism