Sortilin 1 Protein (SORT1) (AA 610-754) (His-SUMO Tag)
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- Target Alle Sortilin 1 (SORT1) Proteine anzeigen
- Sortilin 1 (SORT1)
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 610-754
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Spezies
- Ratte
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses Sortilin 1 Protein ist gelabelt mit His-SUMO Tag.
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- CEENDYTTWL AHSTDPGDYK DGCILGYKEQ FLRLRKSSVC QNGRDYVVAK QPSICPCSLE DFLCDFGYFR PENASECVEQ PELKGHELEF CLYGKEEHLT TNGYRKIPGD RCQGGMNPAR EVKDLKKKCT SNFLNPKKQN SKSSS
- Aufreinigung
- SDS-PAGE
- Reinheit
- > 90 %
- Top Product
- Discover our top product SORT1 Protein
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Sortilin 1 (SORT1) (AA 610-754) protein (His tag)
SORT1 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Sortilin 1 (SORT1) (AA 532-831) protein (His-IF2DI Tag)SORT1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Sortilin 1 (SORT1) (AA 203-299) protein (GST tag)SORT1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Sortilin 1 (SORT1) (AA 610-754) protein (His tag)SORT1 Spezies: Ratte Wirt: Hefe Recombinant > 90 % ELISA
Sortilin 1 (SORT1) (AA 610-754) protein (His-SUMO Tag)SORT1 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Lagerung
- -80 °C,4 °C,-20 °C
- Informationen zur Lagerung
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- Sortilin 1 (SORT1)
- Andere Bezeichnung
- SORT (SORT1 Produkte)
- Hintergrund
- Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
- Molekulargewicht
- 32.5 kDa
- UniProt
- O54861
- Pathways
- Neurotrophin Signalübertragung
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