PTPRB Protein (AA 1643-1997) (His-SUMO Tag)

Produktnummer ABIN5710187

Recombinant PTPRB-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für PTPRB Protein (AA 1643-1997) (His-SUMO Tag) (ABIN5710187)

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 90 %

Produktdetails

Proteineigenschaft: AA 1643-1997

Aufreinigungstag / Konjugat: Dieses PTPRB Protein ist gelabelt mit His-SUMO Tag.

Sequenz: RQKVSHGRER PSARLSIRRD RPLSVHLNLG QKGNRKTSCP IKINQFEGHF MKLQADSNYL LSKEYEELKD VGRNQSCDIA LLPENRGKNR YNNILPYDAT RVKLSNVDDD PCSDYINASY IPGNNFRREY IVTQGPLPGT KDDFWKMVWE QNVHNIVMVT QCVEKGRVKC DHYWPADQDS LYYGDLILQM LSESVLPEWT IREFKICGEE QLDAHRLIRH FHYTVWPDHG VPETTQSLIQ FVRTVRDYIN RSPGAGPTVV HCSAGVGRTG TFIALDRILQ QLDSKDSVDI YGAVHDLRLH RVHMVQTECQ YVYLHQCVRD VLRARKLRSE QENPLFPIYE NVNPEYHRDP VYSRH

Aufreinigung: SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Andere Bezeichnung: PTPRB

Hintergrund: Plays an important role in blood vessel rodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and rodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel rodeling during bryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin .

Molekulargewicht: 57.36 kDa

UniProt: P23467