MMP13 Protein (AA 104-471) (His-SUMO Tag)

Produktnummer ABIN5709941

Dieses Recombinant MMP13-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für MMP13 Protein (AA 104-471) (His-SUMO Tag) (ABIN5709941)

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 90 %

Produktdetails

Proteineigenschaft: AA 104-471

Aufreinigungstag / Konjugat: Dieses MMP13 Protein ist gelabelt mit His-SUMO Tag.

Sequenz: YNVFPRTLKW SKMNLTYRIV NYTPDMTHSE VEKAFKKAFK VWSDVTPLNF TRLHDGIADI MISFGIKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFLVAAHE FGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ SLYGPGDEDP NPKHPKTPDK CDPSLSLDAI TSLRGETMIF KDRFFWRLHP QQVDAELFLT KSFWPELPNR IDAAYEHPSH DLIFIFRGRK FWALNGYDIL EGYPKKISEL GLPKEVKKIS AAVHFEDTGK TLLFSGNQVW RYDDTNHIMD KDYPRLIEED FPGIGDKVDA VYEKNGYIYF FNGPIQFEYS IWSNRIVRVM PANSILWC

Aufreinigung: SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Andere Bezeichnung: MMP13

Hintergrund: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue rodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal bryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Molekulargewicht: 58.3 kDa

UniProt: P45452