ACVA Protein (partial)

Produktnummer ABIN5608399

Produktdetails

Target: ACVA (Activin A (ACVA))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: partial

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Western Blotting (WB), ELISA

Sequenz: Gly 311 - Ser 426

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Biological Activity Comment:

Measured by its binding ability in a functional ELISA. Immobilized Human Activin A, Tag Free at 10 μg/mL (100 uL/well) can bind Human ACVR1B, Fc Tag with a linear range of 0.3-2.5 μg/mL (QC tested).

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for E, WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.056 % TFA in 60 % ACN

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Antigendetails

Target: ACVA (Activin A (ACVA))

Andere Bezeichnung: Activin A (ACVA Produkte)

Synonyme: inhibin beta A subunit Protein, Inhba Protein

Hintergrund: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various beta subunits (betaA, betaB, betaC, and betaE in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two betaA chains. The betaA subunit can also heterodimerize with a betaB or betaC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human betaA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat betaA.

Molekulargewicht: 13 kDa

Gen-ID: 3624

UniProt: P08476

Pathways: Hormone Transport, Peptide Hormone Metabolism