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ACVA Protein (AA 311-426)

ACVA Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN4369364
  • Target Alle ACVA Proteine anzeigen
    ACVA (Activin A (ACVA))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 311-426
    Spezies
    • 11
    • 3
    • 2
    Human
    Quelle
    • 5
    • 5
    • 2
    HEK-293 Cells
    Marke
    ActiveMax®
    Sequenz
    AA 311-426
    Produktmerkmale
    This protein carries no "tag". The protein has a calculated MW of 13 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 0.1 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    0.056 % TFA in 60 % ACN
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution
  • Basu, Bhattacharya, Ray, Mukhopadhyay, Chatterjee, Roy: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." in: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).

  • Target
    ACVA (Activin A (ACVA))
    Andere Bezeichnung
    Activin A /INHBA (ACVA Produkte)
    Synonyme
    inhibin beta A subunit Protein, Inhba Protein
    Hintergrund
    Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.
    Molekulargewicht
    13.0 kDa
    Pathways
    Hormone Transport, Peptide Hormone Metabolism
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