EPH Receptor A6 Protein (Epha6)

Produktnummer ABIN2746574

Recombinant EPH Receptor A6-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für EPH Receptor A6 Protein (Epha6) (ABIN2746574)

Target: EPH Receptor A6 (Epha6)

Protein-Typ: Recombinant

Spezies: Maus, Human, Ratte

Quelle: Escherichia coli (E. coli)

Applikation: Western Blotting (WB), Positive Control (PC)

Produktdetails

Verwendungszweck: Purified Protein in ready-to-use SDS sample buffer.

Aufreinigung: Purified Protein

Anwendungsinformationen

Applikationshinweise: The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.

Lagerung: -20 °C

Informationen zur Lagerung: -20 °C for long term storage

Antigendetails

Target: EPH Receptor A6 (Epha6)

Andere Bezeichnung: Eprhin Receptor A6

Hintergrund: Ephrin A6, a member of the ephrin family, elicits biological responses in retinal neurons. It binds with high affinity to several other EphA receptors and causes growth cone collapse in retinal explants. Ephrin-A6 expression is high at embryonic day 6 (E6) and at embryonic day 8 (E8), when retinal axons grow to their tectal targets, and then this Ephrin-A6 expression gradually declines at later developmental stages. This new ephrin plays a role in the establishment of visual system topography as observed by the asymmetric distribution of ephrin-A6 in retinal cells. High levels of expression of Eph-A6 in the macula of developing human retina showed localization of Eph-A6 to (GC) ganglion cells. Eph receptors and Ephrins have indeed been implicated in multiple aspects of synaptic function, including clustering and modulating N-methyl-D-aspartate receptors, modifying the geometry of postsynaptic terminals, and influencing long-term synaptic plasticity and memory. Eph A6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits of learning and memory. Genetic inhibition of the ephrin receptor (Eph A6) in knockout mice produced behavioral deficits in tests of learning and memory. The gene for EphAR6 is present on chromosome 3q11.2

Molekulargewicht: 136 kDa

NCBI Accession: NP_001073917

UniProt: B3KS12

Pathways: RTK Signalweg