EPH Receptor A5 Protein (EPHA5)

Produktnummer ABIN2746570

Dieses Recombinant EPH Receptor A5-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für EPH Receptor A5 Protein (EPHA5) (ABIN2746570)

Target: EPH Receptor A5 (EPHA5)

Protein-Typ: Recombinant

Spezies: Maus, Ratte

Quelle: Escherichia coli (E. coli)

Applikation: Positive Control (PC), Western Blotting (WB)

Produktdetails

Verwendungszweck: Purified Protein in ready-to-use SDS sample buffer.

Aufreinigung: Purified Protein

Anwendungsinformationen

Applikationshinweise: The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.

Lagerung: -20 °C

Informationen zur Lagerung: -20 °C for long term storage

Antigendetails

Target: EPH Receptor A5 (EPHA5)

Andere Bezeichnung: Eprhin Receptor A5

Hintergrund: The Ephrin receptors represent the largest group of Receptor Tyrosine Kinases, comprising of 14 members and divided in two subclasses (class A & B ephrin ligands) based on their abilities to bind and activate each other, and on sequence conservation. Ephrin-A (EFNA) class is anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) classes are trans-membrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrins interact with a variety of membrane receptors that respond to chemokines, neurotransmitters or growth factors. Eph receptors are involved in central nervous system function and development, and in the modulation of different types of nociception. Eph receptors and their ligands play important roles in the regulation of cancer cell migration and invasion and are key regulators of axon guidance. They function in a variety of signaling modes by transducing signals from the cell exterior to the interior through ligand-induced activation of their kinase domain. Ephrin A5, a member of the ephrin family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. Ephrin-A5 is highly expressed in the developing nervous system in several brain regions including the olfactory bulb, frontal cortex, striatum and hypothalamus. Ephrin-A5 acts as a guidance molecule regulating the trajectory of the ascending midbrain dopaminergic pathways. Ephrin- A5 expression is critical for proper development of central monoaminergic pathways and that its loss results in various neurodevelopmental abnormalities. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and mediate developmental events in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EphrinA5 possesses two alternative isoforms, large ephrinA5 isoform (ephrinA5L) and small ephrinA5 isoform (ephrinA5S). EphrinA5L is a putative tumor suppressor in several types of human cancers and ephrin A5S, acts as a tumor suppressor specifically in human hepatocellular carcinomas (HCC).The gene for EphA R5 is present on chromosome 5q21

Molekulargewicht: 124 kDa

NCBI Accession: NP_004430

UniProt: P54756

Pathways: RTK Signalweg