GREM1 Protein (Transcript Variant 1)
Kurzübersicht für GREM1 Protein (Transcript Variant 1) (ABIN2722232)
Target
Alle GREM1 Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- Transcript Variant 1
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Spezifität
- Optimal preservation of protein structure, post-translational modifications and functions.
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Produktmerkmale
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- Recombinant human Gremlin-1 / GREM1 (transcript variant 1) protein expressed in CHO cells.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
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Endotoxin-Niveau
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
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Biological Activity Comment
- Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11ug/mL.
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Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
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Handhabung
- Resuspend the protein in the desired concentration in proper buffer
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Lagerung
- -80 °C
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Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- GREM1 (Gremlin 1 (GREM1))
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Andere Bezeichnung
- Gremlin-1,grem1
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Hintergrund
- This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Molekulargewicht
- 18.3 kDa
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NCBI Accession
- NP_037504
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Pathways
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
Target
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