GREM1 Protein (AA 25-184) (His tag)

Produktnummer ABIN4949103

Produktdetails

Target: GREM1 (Gremlin 1 (GREM1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 25-184

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GREM1 Protein ist gelabelt mit His tag.

Applikation: Functional Studies (Func)

Sequenz: AA 25-184

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.2 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4 with 1 mM EDTA

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: GREM1 (Gremlin 1 (GREM1))

Andere Bezeichnung: Gremlin (GREM1 Produkte)

Synonyme: grem1 Protein, MGC136702 Protein, zgc:136702 Protein, GREM1 Protein, drm Protein, pig2 Protein, dand2 Protein, ihg-2 Protein, gremlin Protein, Cktsf1b1 Protein, Drm Protein, Grem Protein, ld Protein, gremlin-1 Protein, CKTSF1B1 Protein, DAND2 Protein, DRM Protein, GREMLIN Protein, IHG-2 Protein, cktsf1b1 Protein, gremlin 1a, DAN family BMP antagonist Protein, gremlin 1, DAN family BMP antagonist Protein, gremlin 1 Protein, gremlin 1, DAN family BMP antagonist L homeolog Protein, grem1a Protein, GREM1 Protein, LOC662541 Protein, grem1 Protein, Grem1 Protein, grem1.L Protein

Hintergrund: Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Molekulargewicht: 20.2 kDa

NCBI Accession: NP_037504

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location