MANF Protein (Mesencephalic Astrocyte-Derived Neurotrophic Factor) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2714930

Produktdetails

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MANF Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ARMET / ARP protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Andere Bezeichnung: Armet,arp (MANF Produkte)

Synonyme: ARMET, ARP, 3230402M22Rik, AA407711, AA408789, AA673178, Armet, D17914, D18Mgi17, MANF, RBM15B, ARP-like, CG7013, DmMANF, Dmel\\CG7013, anon-EST:ParkEST188, arp, armet, im:6909481, zgc:153327, manf, mesencephalic astrocyte derived neurotrophic factor, mesencephalic astrocyte-derived neurotrophic factor, RNA binding motif protein 15B, Mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte-derived neurotrophic factor S homeolog, MANF, Manf, RBM15B, manf, manf.S

Hintergrund: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Molekulargewicht: 18.1 kDa

NCBI Accession: NP_006001