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MANF Protein

MANF Spezies: Human Wirt: CHO Cells Recombinant WB, SDS, CC, in vivo Active
Produktnummer ABIN1405920
  • Target Alle MANF Proteine anzeigen
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 10
    • 2
    • 1
    • 1
    Human
    Quelle
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    CHO Cells
    Applikation
    Western Blotting (WB), SDS-PAGE (SDS), Cell Culture (CC), In vivo Studies (in vivo)
    Produktmerkmale
    Bio-activity testing: Protein is biologically active. Suitable for cell culture and in vivo testing. Human recombinant MANF has been tested in rat &-OHDA model of Parkinson's disease and shown neureprotection and neurorestoration. MANF has also shown neuroprotection in animal models of stroke
    Aufreinigung
    Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media.
    Purified Protein is characterized as homogenous material by mass-spectroscopy.
    Endotoxin-Niveau
    Less than 1EU/µg of protein as determined by LAL method
  • Kommentare

    Synonyms: Mesencephalic astrocyte-derived neurotrophic factor - MANF, ARMET, ARP

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/ml Concentration of the protein is determined by BCA Protein Analysis kit (Pierce). BSA was used as a standard
    Buffer
    PBS pH 7.4
    Handhabung
    Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles.
    Lagerung
    -80 °C
  • Target
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Andere Bezeichnung
    MANF (MANF Produkte)
    Synonyme
    ARMET Protein, ARP Protein, 3230402M22Rik Protein, AA407711 Protein, AA408789 Protein, AA673178 Protein, Armet Protein, D17914 Protein, D18Mgi17 Protein, MANF Protein, RBM15B Protein, ARP-like Protein, CG7013 Protein, DmMANF Protein, Dmel\\CG7013 Protein, anon-EST:ParkEST188 Protein, arp Protein, armet Protein, im:6909481 Protein, zgc:153327 Protein, manf Protein, mesencephalic astrocyte derived neurotrophic factor Protein, mesencephalic astrocyte-derived neurotrophic factor Protein, RNA binding motif protein 15B Protein, Mesencephalic astrocyte-derived neurotrophic factor Protein, mesencephalic astrocyte-derived neurotrophic factor S homeolog Protein, MANF Protein, Manf Protein, RBM15B Protein, manf Protein, manf.S Protein
    Hintergrund
    MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
    Molekulargewicht
    Approximately 18.1 kDa, a single non-glycosylated polypeptide chain containing 163 amino acids.
    UniProt
    P55145
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