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FE65 Protein (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65)) (Transcript Variant 1) (Myc-DYKDDDDK Tag)

APBB1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2714775
$1,112.40
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
20 μg
Lieferung in 11 Werktagen
  • Target Alle FE65 (APBB1) Proteine anzeigen
    FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Transcript Variant 1
    Spezies
    • 6
    • 1
    • 1
    Human
    Quelle
    • 3
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FE65 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human APBB1 / FE65 (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
    Andere Bezeichnung
    Apbb1,fe65 (APBB1 Produkte)
    Synonyme
    FE65, MGC:9072, RIR, apbb1, MGC80654, Fe65, Rir, amyloid beta precursor protein binding family B member 1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog, amyloid beta (A4) precursor protein-binding, family B, member 1, APBB1, apbb1.L, Apbb1
    Hintergrund
    The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer&aposs disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product&aposs nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer&aposs disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
    Molekulargewicht
    77.1 kDa
    NCBI Accession
    NP_001155
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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