alpha 2 Macroglobulin Protein (Myc-DYKDDDDK Tag)
Kurzübersicht für alpha 2 Macroglobulin Protein (Myc-DYKDDDDK Tag) (ABIN2714610)
Target
Alle alpha 2 Macroglobulin (A2M) Proteine anzeigenProtein-Typ
Spezies
Quelle
Applikation
Reinheit
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                                            Aufreinigungstag / Konjugat
- Dieses alpha 2 Macroglobulin Protein ist gelabelt mit Myc-DYKDDDDK Tag.
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                                            Produktmerkmale
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                        - Recombinant human Alpha-2-macroglobulin / A2M protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
 
 
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                                            Applikationshinweise
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                        Recombinant human proteins can be used for:
 Native antigens for optimized antibody production
 Positive controls in ELISA and other antibody assays
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                                            Kommentare
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                        The tag is located at the C-terminal. 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Konzentration
- 50 μg/mL
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                                            Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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                                            Lagerung
- -80 °C
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                                            Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
 
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    - alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
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                                            Andere Bezeichnung
- alpha-2-Macroglobulin
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                                            Hintergrund
- Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. [UniProtKB/Swiss-Prot Function]
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                                            Molekulargewicht
- 160.8 kDa
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                                            NCBI Accession
- NP_000005
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                                            Pathways
- Lipid Metabolism
 Target
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