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CXCL12 Protein (Transcript Variant 1)

CXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 98 % , as determined by Coomassie stained SDS-PAGE. Func, AbP, STD, PI Active
Produktnummer ABIN2712669
  • Target Alle CXCL12 Proteine anzeigen
    CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    Transcript Variant 1
    Spezies
    • 26
    • 14
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 43
    • 3
    • 3
    • 1
    • 1
    Escherichia coli (E. coli)
    Applikation
    Functional Studies (Func), Antibody Production (AbP), Standard (STD), Protein Interaction (PI)
    Spezifität
    Optimal preservation of protein structure, post-translational modifications and functions.
    Produktmerkmale
    • Recombinant human CXCL12 / SDF1 (transcript variant 1) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Reinheit
    > 98 % , as determined by Coomassie stained SDS-PAGE.
    Endotoxin-Niveau
    Less than 0.1 EU/μg (<0.01 ng/μg) protein as determined by the LAL method.
    Biological Activity Comment
    The ED50 is 80 - 120 ng/ml, corresponding to a specific activity of 1.25-0.83 x 10^4 units/mg.
    Top Product
    Discover our top product CXCL12 Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    > 50 μg/mL
    Buffer
    20 mM Tris pH 8.0, 0.5M NaCl
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
    Andere Bezeichnung
    Cxcl12,sdf1 (CXCL12 Produkte)
    Hintergrund
    This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
    Molekulargewicht
    8.0 kDa
    NCBI Accession
    NP_954637
    Pathways
    Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
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