CXCL12 Protein (AA 24-89) (Biotin)
Kurzübersicht für CXCL12 Protein (AA 24-89) (Biotin) (ABIN6952225)
Target
Alle CXCL12 Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- AA 24-89
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Aufreinigungstag / Konjugat
- Dieses CXCL12 Protein ist gelabelt mit Biotin.
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Sequenz
- KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
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Produktmerkmale
- Biotininylated Recombinant Human CXCL12 (SDF-1alpha)
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Endotoxin-Niveau
- <0.01 EU per 1μg of the protein by the LAL method
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Biological Activity Comment
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EC50 = 0.5-0.9 nM determined by Calcium Flux with human CXCR4 in U937 cells
Migration confirmed with U937 cells expressing CXCR4
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Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) (Active) protein (His tag,GST tag)
CXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) > 97 % CC, AcA Active
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % It contains no nucleic acids. Act, CA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) protein (His tag)CXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) protein (His tag)CXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) protein (His-IF2DI Tag)CXCL12 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) protein (His-IF2DI Tag)CXCL12 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 1-89) protein (GST tag)CXCL12 Spezies: Human Wirt: Wheat germ Recombinant AP, AA, ELISA, WB
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93), (full length) protein (hFc Tag)CXCL12 Spezies: Maus Wirt: Mammalian Cells Recombinant Greater than 90 % as determined by SDS-PAGE.
Chemokine (C-X-C Motif) Ligand 12 (CXCL12) proteinCXCL12 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
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12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution. -
Haltbarkeit
- 12 months
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- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
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Andere Bezeichnung
- CXCL12/SDF-1alpha
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Hintergrund
- Stromal-Cell Derived Factor-1alpha (SDF-1alpha) (CXCL12) attracts lymphocytes and plays important roles in embryogenesis and angiogenesis with implications in tumor metastasis. By binding to CXCR4, one of the co-receptors for HIV viral entry, SDF-1alpha can suppress HIV. Besides CXCR4, SDF-1alpha also binds to the “decoy” receptor CXCR7, and activates the downstream beta-arrestin- rather than G protein-mediated signaling pathway.
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Molekulargewicht
- 10.381 kDa
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UniProt
- P48061
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Pathways
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
Target
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