Patched 1 Protein (PTCH1) (DYKDDDDK Tag)

Produktnummer ABIN2712353

Recombinant Patched 1-Protein exprimiert in Insect cells (Sf9).

Kurzübersicht für Patched 1 Protein (PTCH1) (DYKDDDDK Tag) (ABIN2712353)

Target: Patched 1 (PTCH1)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Insect cells (Sf9)

Applikation: Antibody Production (AbP), Standard (STD)

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Produktdetails

Aufreinigungstag / Konjugat: Dieses Patched 1 Protein ist gelabelt mit DYKDDDDK Tag.

Produktmerkmale:

• Recombinant human PTCH1 (C-term DDK tag, transcript variant 1b) protein expressed in Sf9 cells.
• Produced with end-sequenced ORF clone

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Patched 1 (PTCH1)

Andere Bezeichnung: Ptch1

Hintergrund: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Molekulargewicht: 30.4 kDa

NCBI Accession: NP_000255

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation