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Thrombopoietin Protein (THPO) (AA 22-195)

THPO Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis. BCA Active
Produktnummer ABIN2667585
  • Target Alle Thrombopoietin (THPO) Proteine anzeigen
    Thrombopoietin (THPO)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 22-195
    Spezies
    • 14
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    Maus
    Quelle
    • 23
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Applikation
    Biochemical Assay (BCA)
    Reinheit
    >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
    Endotoxin-Niveau

    Less than 0.1 ng per μg of protein.

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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Biological activity: The expected ED50 is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg, as determined by the dose-dependent stimulation of the proliferation of human MO7e cells.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-0.5 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
    Buffer
    Lyophilized, carrier-free.
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Unopened vial can be stored at -20°C or -70°C.
  • Target
    Thrombopoietin (THPO)
    Andere Bezeichnung
    Thrombopoietin (THPO Produkte)
    Synonyme
    MGDF Protein, MKCSF Protein, ML Protein, MPLLG Protein, THCYT1 Protein, TPO Protein, Mgdf Protein, Ml Protein, Mpllg Protein, Tpo Protein, Tpo1 Protein, Tpo2 Protein, Tpo3 Protein, Tpo4 Protein, tpo Protein, LOC100231762 Protein, thrombopoietin Protein, THPO Protein, Thpo Protein, thpo Protein
    Hintergrund
    Mouse Thrombopoietin (TPO) is a protein consisting of an N-terminus domain with homology to erythropoietin (EPO) and a C-terminus domain with multiple N-linked and O-linked glycosylation sites. TPO is a key regulator of megakaryocytopoiesis and thrombopoiesis. It signals through the c-mpl receptor and stimulates the proliferation and maturation of megakaryocytes, hence, TPO plays an important role in regulating the level of circulating platelets in vivo. It has also been shown that TPO is able to promote the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitors. Besides its hematopoietic effects, TPO is expressed in the brain where it promotes apoptosis of hypoxia sensitized neurons and inhibits neuronal differentiation by blocking NGF induced signaling.
    Molekulargewicht
    The 174 amino acid recombinant protein has a predicted molecular mass of 18.7 kDa. The predicted N-terminal amino acid is Ser.
    Pathways
    JAK-STAT Signalweg, Hormone Activity
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