XBP1 Protein (AA 2-160) (His tag)

Produktnummer ABIN2469226

Recombinant XBP1-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für XBP1 Protein (AA 2-160) (His tag) (ABIN2469226)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)

Reinheit: ~95 %

Produktdetails

Proteineigenschaft: AA 2-160

Aufreinigungstag / Konjugat: Dieses XBP1 Protein ist gelabelt mit His tag.

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1X PBS containing 0.1 % SDS

Handhabung: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lagerung: -80 °C

Informationen zur Lagerung: Store in working aliquots at -70 °C.

Antigendetails

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1

Hintergrund: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).

Molekulargewicht: 25 kDa (Calculated)

Gen-ID: 7494

OMIM: 18148382

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response