VEGF 165 (Active) Protein
Kurzübersicht für VEGF 165 (Active) Protein (ABIN2469210)
Target
Protein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Sequenz
- MAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
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Produktmerkmale
- Biological activity was determined by the dose - dependent stimulation of the proliferation of Human umbilical vein endothelial cells (HUVEC). The expected ED50 is 4.0 - 8.0 ng/mL.
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Endotoxin-Niveau
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Handhabung
- As with any protein, exposing VEGF165 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted VEGF165 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Haltbarkeit
- 24 months
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- VEGF 165
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Andere Bezeichnung
- VEGF165
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Hintergrund
- VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors , fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant rat VEGF is a 38.5 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
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Gen-ID
- 83785
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NCBI Accession
- NP_001103803
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OMIM
- 160358793
Target
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