Calreticulin Protein (CALR) (AA 18-417)

Produktnummer ABIN2468306

Dieses Recombinant Calreticulin-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Calreticulin Protein (CALR) (AA 18-417) (ABIN2468306)

Target: Calreticulin (CALR)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Western Blotting (WB), ELISA, Mass Spectrometry (MS)

Reinheit: ~90 %

Produktdetails

Proteineigenschaft: AA 18-417

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB, ELISA, MS.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Tris, pH 8.0, 0.002 % NaN, 3 mM NaCl, 2.5 mM

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lagerung: -80 °C

Informationen zur Lagerung: Store in working aliquots at -70 °C.

Antigendetails

Target: Calreticulin (CALR)

Andere Bezeichnung: CALR

Hintergrund: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.

Molekulargewicht: 46 kDa (Calculated)

Gen-ID: 811

NCBI Accession: NP_004334

OMIM: 4757900

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response