VLDLR
(Very Low Density Lipoprotein Receptor (VLDLR))
Protein-Typ
Recombinant
Biologische Aktivität
Active
Proteineigenschaft
AA 28-769
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses VLDLR Protein ist gelabelt mit His tag.
Sequenz
AA 28-769
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 83 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Target
VLDLR
(Very Low Density Lipoprotein Receptor (VLDLR))
The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene. A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.