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VEGF Protein (AA 27-191) (Biotin)

Recombinant VEGF-Protein exprimiert in HEK-293 Cells und wurde in 1 Publikation erwähnt.
Produktnummer ABIN2181906

Kurzübersicht für VEGF Protein (AA 27-191) (Biotin) (ABIN2181906)

Target

Alle VEGF Proteine anzeigen
VEGF (Vascular Endothelial Growth Factor (VEGF))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 11
  • 6
  • 1
  • 1
Human

Quelle

  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

>95 % as determined by reduced SDS-PAGE.
  • Proteineigenschaft

    AA 27-191

    Aufreinigungstag / Konjugat

    Dieses VEGF Protein ist gelabelt mit Biotin.

    Marke

    MABSol®,UltraLys

    Sequenz

    AA 27-191

    Spezifität

    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.

    Produktmerkmale

    The product does NOT contain any epitope tags. The protein has a calculated MW of 19 kDa (monomer). The protein migrates as 24 kDa (monomer) on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 43-50 kDa under non-reducing (NR) condition.

    Sterilität

    0.22 μm filtered

    Endotoxin-Niveau

    Less than 1.0 EU per μg by the LAL method.
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  • Kommentare

    A chemically labeled biotinylated protein with ultra sensitivity.
    The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
    Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handhabung

    Please avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • McGonigle, Majumder, Kolber-Simonds, Wu, Hart, Noland, TenDyke, Custar, Li, Du, Postema, Lai, Twine, Woodall-Jappe, Nomoto: "Neuropilin-1 drives tumor-specific uptake of chlorotoxin." in: Cell communication and signaling : CCS, Vol. 17, Issue 1, pp. 67, (2019) (PubMed).

  • Target

    VEGF (Vascular Endothelial Growth Factor (VEGF))

    Andere Bezeichnung

    VEGF

    Hintergrund

    VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.

    Molekulargewicht

    19.2 kDa

    NCBI Accession

    NP_001165097
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