TNFRSF6B
(Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))
Protein-Typ
Recombinant
Proteineigenschaft
AA 30-300
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses TNFRSF6B Protein ist gelabelt mit Fc Tag.
Sequenz
AA 30-300
Produktmerkmale
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.4 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
TNFRSF6B
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 85 % by SDS - PAGE
SDS
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
Tris with Glycine, Arginine and NaCl, pH 7.5
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Target
TNFRSF6B
(Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.