TNFRSF6B Protein (AA 24-300) (Fc Tag)

Produktnummer ABIN6253317

Produktdetails

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-300

Spezies: Human

Quelle: CHO Cells

Aufreinigungstag / Konjugat: Dieses TNFRSF6B Protein ist gelabelt mit Fc Tag.

Verwendungszweck: DcR3 (human):Fc (human) (rec.)

Spezifität: The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1.

Produktmerkmale: Protein. The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Decoy receptor 3 (DcR3, TNFRSF6B, M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31 %), TNF-RII (29 %) and Fas (17 %) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.

Reinheit: >98 % (SDS-PAGE)

Endotoxin-Niveau: <0.06EU/μg protein (LAL test, Lonza).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Andere Bezeichnung: DcR3 (TNFRSF6B Produkte)

Synonyme: DCR3 Protein, DJ583P15.1.1 Protein, M68 Protein, M68E Protein, TR6 Protein, dcr3 Protein, m68 Protein, tr6 Protein, TNF receptor superfamily member 6b Protein, tumor necrosis factor receptor superfamily, member 11b Protein, regulator of telomere elongation helicase 1 Protein, TNF receptor superfamily member 6b L homeolog Protein, TNFRSF6B Protein, tnfrsf11b Protein, RTEL1 Protein, tnfrsf6b Protein, tnfrsf6b.L Protein

Hintergrund:

Alternate Names/Synonyms: Decoy Receptor 3, Tumor Necrosis Factor Receptor Superfamily Member 6B, TNFRSF6B, M68

Product Description: Decoy receptor 3 (DcR3, TNFRSF6B, M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31 % ), TNF-RII (29 %) and Fas (17 %) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.

UniProt: O95407