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R-Spondin 1 (RSPO1) (AA 21-263) protein (His tag)

RSPO1 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Pubmed (3 Referenzen)
Produktnummer ABIN2181684
$385.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle RSPO1 Proteine anzeigen
    RSPO1
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 21-263
    Spezies
    • 8
    • 4
    • 3
    Human
    Quelle
    • 6
    • 3
    • 3
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses RSPO1 Protein ist gelabelt mit His tag.
    Sequenz
    AA 21-263
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.6 kDa. The protein migrates as 40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Igarashi, Miura, Williams, Jaksch, Kadowaki, Yamauchi, Guarente: "NAD+ supplementation rejuvenates aged gut adult stem cells." in: Aging cell, Vol. 18, Issue 3, pp. e12935, (2020) (PubMed).

    Park, Choi, Kim, Cheong, Jeong: "AhR activation by 6-formylindolo[3,2-b]carbazole and 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibit the development of mouse intestinal epithelial cells." in: Environmental toxicology and pharmacology, Vol. 43, pp. 44-53, (2017) (PubMed).

    Das, Png, Oancea, Hasnain, Lourie, Proctor, Eri, Sheng, Crane, Florin, McGuckin: "Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins." in: The Journal of experimental medicine, Vol. 210, Issue 6, pp. 1201-16, (2013) (PubMed).

  • Target
    RSPO1
    Andere Bezeichnung
    R-Spondin 1 (RSPO1 Produkte)
    Synonyme
    RGD1565558, CRISTIN3, RSPO, R-spondin, Rspondin, wu:fj81e05, zgc:92153, R-spondin 1, Rspo1, RSPO1, LOC100049655, rspo1
    Hintergrund
    R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.
    Molekulargewicht
    28.7 kDa
    NCBI Accession
    NP_001033722
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