Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) (AA 20-469) protein (His tag)

Produktnummer ABIN2181513

Produktdetails

Target: MMP 9 (MMP9)

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-469

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MMP 9 Protein ist gelabelt mit His tag.

Sequenz: AA 20-469

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.8 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50  mM Tris, 150  mM NaCl, pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: MMP 9 (MMP9)

Andere Bezeichnung: MMP-9 (MMP9 Produkte)

Synonyme: CLG4B, GELB, MANDP2, MMP-9, AW743869, B/MMP9, Clg4b, pro-MMP-9, mmp-9, fgMMP-9, mmp9, ZFMMP-9, wu:fb02g06, wu:fb07b05, wu:fi98c09, wu:fj05a08, zgc:64165, clg4b, gelb, mandp2, matrix metallopeptidase 9, collagenase, matrix metalloproteinase 9, matrix metallopeptidase 9 S homeolog, MMP9, RB3913, BPSS0666, Sbal_3732, Bcer98_0486, Shew185_0630, Shal_3056, Sbal195_0657, Lbys_3550, Palpr_2084, Mmp9, mmp9, mmp9.S

Hintergrund: Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

Molekulargewicht: 50.8 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events