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Interleukin 7 (IL7) (AA 26-177) (Active) Protein Protein

IL7 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN2181324
$536.80
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle IL-7 (IL7) Proteine anzeigen
    IL-7 (IL7)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 26-177
    Spezies
    • 18
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 17
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Marke
    ActiveMax®
    Sequenz
    AA 26-177
    Produktmerkmale
    This protein carries no "tag". The protein has a calculated MW of 17 kDa. The protein migrates as 24 kDa and 26 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    IL-7 (IL7)
    Andere Bezeichnung
    IL-7 (IL7 Produkte)
    Synonyme
    IL7, IL-7, A630026I06Rik, Il-7, hlb368, interleukin 7, IL7, Il7
    Hintergrund
    Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.
    Molekulargewicht
    17.4 kDa
    Pathways
    JAK-STAT Signalweg
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