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Folate Receptor 2 (Fetal) (FOLR2) (AA 17-228) protein (His tag) Protein

FOLR2 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Produktnummer ABIN2181119
$253.00
Zzgl. Versandkosten $45.00
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  • Target Alle FOLR2 Proteine anzeigen
    FOLR2
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 17-228
    Spezies
    • 8
    • 1
    • 1
    Human
    Quelle
    • 6
    • 2
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FOLR2 Protein ist gelabelt mit His tag.
    Sequenz
    AA 17-228
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris and Glycine, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    FOLR2
    Andere Bezeichnung
    FOLR2 (FOLR2 Produkte)
    Synonyme
    FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, FBP2, Folbp-2, Folbp2, folate receptor 1, folate receptor beta, folate receptor 2 (fetal), FOLR1, FOLR2, Folr2
    Hintergrund
    Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68 % and 79 % sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
    Molekulargewicht
    26.5 kDa
    NCBI Accession
    NP_000794
    Pathways
    Dicarboxylic Acid Transport
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