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Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) Protein Protein

FLT3LG Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2181107
$374.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle FLT3LG Proteine anzeigen
    FLT3LG
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 27-185
    Spezies
    • 23
    • 13
    • 2
    • 1
    Human
    Quelle
    • 14
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Marke
    ActiveMax®
    Sequenz
    AA 27-185
    Produktmerkmale
    This protein carries no "tag". The protein has a calculated MW of 18.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    FLT3LG
    Andere Bezeichnung
    Flt-3 Ligand (FLT3LG Produkte)
    Synonyme
    Flt3lg, Ly72L, FL, FLT3L, Vegfr3, fms related tyrosine kinase 3 ligand, FMS-like tyrosine kinase 3 ligand, fms-related tyrosine kinase 4, fms-related tyrosine kinase 3 ligand, FLT3LG, Flt3l, Flt4, Flt3lg
    Hintergrund
    FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
    Molekulargewicht
    18.0 kDa
    Pathways
    RTK Signalweg
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