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FLT3LG Protein (AA 27-185)

Dieses Recombinant FLT3LG-Protein wird in HEK-293 Cells produziert.
Produktnummer ABIN2181107

Kurzübersicht für FLT3LG Protein (AA 27-185) (ABIN2181107)

Target

Alle FLT3LG Proteine anzeigen
FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))

Protein-Typ

Recombinant

Spezies

  • 31
  • 19
  • 1
  • 1
Human

Quelle

  • 20
  • 12
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

>95 % as determined by SDS-PAGE.
  • Proteineigenschaft

    AA 27-185

    Marke

    ActiveMax®

    Sequenz

    AA 27-185

    Produktmerkmale

    This protein carries no "tag". The protein has a calculated MW of 18.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE).

    Sterilität

    0.22 μm filtered

    Endotoxin-Niveau

    Less than 1.0 EU per μg by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handhabung

    Please avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target

    FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))

    Andere Bezeichnung

    Flt-3 Ligand

    Hintergrund

    FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.

    Molekulargewicht

    18.0 kDa

    Pathways

    RTK Signalweg
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