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Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 20-643) protein (Fc Tag) Protein

ERBB3 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2181037
$374.00
Zzgl. Versandkosten $45.00
Lieferung in 5 Werktagen
  • Target Alle ERBB3 Proteine anzeigen
    ERBB3
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 20-643
    Spezies
    • 21
    • 5
    • 3
    Human
    Quelle
    • 13
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ERBB3 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 20-643
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 95.4 kDa. The protein migrates as 130-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    ERBB3
    Andere Bezeichnung
    ErbB3 (ERBB3 Produkte)
    Synonyme
    ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, ERBB3, C76256, Erbb-3, Erbb3r, Her3, nuc-ErbB3, erb-b2 receptor tyrosine kinase 3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), ERBB3, Erbb3
    Hintergrund
    ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
    Molekulargewicht
    94.8 kDa
    NCBI Accession
    NP_001973
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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