ERBB3 Protein (AA 20-643) (Fc Tag)

Produktnummer ABIN2181037

Produktdetails

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-643

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ERBB3 Protein ist gelabelt mit Fc Tag.

Sequenz: AA 20-643

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 95.4 kDa. The protein migrates as 130-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Antigendetails

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Andere Bezeichnung: ErbB3 (ERBB3 Produkte)

Synonyme: ErbB-3 Protein, HER3 Protein, LCCS2 Protein, MDA-BF-1 Protein, c-erbB-3 Protein, c-erbB3 Protein, erbB3-S Protein, p180-ErbB3 Protein, p45-sErbB3 Protein, p85-sErbB3 Protein, ERBB3 Protein, C76256 Protein, Erbb-3 Protein, Erbb3r Protein, Her3 Protein, nuc-ErbB3 Protein, erb-b2 receptor tyrosine kinase 3 Protein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Protein, ERBB3 Protein, Erbb3 Protein

Hintergrund: ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Molekulargewicht: 94.8 kDa

NCBI Accession: NP_001973

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung