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CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) protein (His tag) Protein

CD3D Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Produktnummer ABIN2180772
$346.50
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle CD3D Proteine anzeigen
    CD3D
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 22-105
    Spezies
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Quelle
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD3D Protein ist gelabelt mit His tag.
    Sequenz
    AA 22-105
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11 kDa. The protein migrates as 18-25 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    CD3D
    Andere Bezeichnung
    CD3 delta (CD3D Produkte)
    Synonyme
    CD3-DELTA, T3D, CD3, T3d, CD3d molecule, CD3 antigen, delta polypeptide, CD3D, Cd3d
    Hintergrund
    CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
    Molekulargewicht
    11.4 kDa
    NCBI Accession
    NP_000723
    Pathways
    T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events
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