CD3D Protein (AA 22-105) (His tag)

Produktnummer ABIN2180772

Recombinant CD3D-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für CD3D Protein (AA 22-105) (His tag) (ABIN2180772)

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: >90 % as determined by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 22-105

Aufreinigungstag / Konjugat: Dieses CD3D Protein ist gelabelt mit His tag.

Sequenz: AA 22-105

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11 kDa. The protein migrates as 18-25 kDa under reducing (R) condition (SDS-PAGE).

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Antigendetails

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Andere Bezeichnung: CD3 delta

Hintergrund: CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

Molekulargewicht: 11.4 kDa

NCBI Accession: NP_000723

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events