C5A Protein (AA 679-751)

Produktnummer ABIN2180666

Dieses Recombinant C5A-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für C5A Protein (AA 679-751) (ABIN2180666)

Target: C5A (C5a) (Complement Component 5a (C5a))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: >95 % as determined by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 679-751

Sequenz: AA 679-751

Produktmerkmale: This protein carries no "tag". The protein has a calculated MW of 8.3 kDa. The protein migrates as 8.3 kDa under reducing (R) condition (SDS-PAGE).

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Antigendetails

Target: C5A (C5a) (Complement Component 5a (C5a))

Andere Bezeichnung: Complement Component C5a

Hintergrund: Human Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells, C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation, C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism, C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system, C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Molekulargewicht: 8.3 kDa

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis