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Met Proto-Oncogene (MET) (AA 25-932) protein (Fc Tag) Protein

MET Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Produktnummer ABIN2180662
$418.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle c-MET (MET) Proteine anzeigen
    c-MET (MET)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 25-932
    Spezies
    • 25
    • 5
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 21
    • 9
    • 3
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses c-MET Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 25-932
    Produktmerkmale
    rhHGFR is fused with Fc fragment of human IgG1 at the C-terminus. The mature form of HGFR is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. Each α and β chain has a calculated MW of 32.5 kDa (α chain) and 96.7 kDa (β chain Fc chimera). The predicted N-terminal is Glu25 (α chain) & Ser308 (β chain Fc chimera). Protein migrates as 45 kDa (α chain) and 120-125 kDa (βchain Fc chimera) in reduced SDS-PAGE resulting from glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    c-MET (MET)
    Andere Bezeichnung
    HGF R (MET Produkte)
    Synonyme
    AUTS9, HGFR, RCCP2, c-Met, AI838057, HGF, Par4, Hgfr, c-met, MET, C-MET, met, met-A, MET proto-oncogene, receptor tyrosine kinase, met proto-oncogene, MET proto-oncogene, receptor tyrosine kinase L homeolog, MET, Met, met.L
    Hintergrund
    Hepatocyte growth factor receptor (HGFR) is also known as mesenchymal-epithelial transition factor (MET), c-Met, and is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGFR protein possesses tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. HGFR is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, HGFR induces several biological responses that collectively give rise to a program known as invasive growth. Abnormal HGFR activation in cancer correlates with poor prognosis, where aberrantly active HGFR triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). HGFR is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express HGFR, However, cancer stem cells are thought to hijack the ability of normal stem cells to express HGFR, and thus become the cause of cancer persistence and spread to other sites in the body. Various mutations in the HGFR gene are associated with papillary renal carcinoma. HGFR mediates a complex program known as invasive growth. Activation of HGFR triggers mitogenesis, and morphogenesis.
    Molekulargewicht
    127.8 kDa
    Pathways
    RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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