ANGPTL4 Protein (AA 166-406) (His tag)

Produktnummer ABIN2180590

Produktdetails

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Protein-Typ: Recombinant

Proteineigenschaft: AA 166-406

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ANGPTL4 Protein ist gelabelt mit His tag.

Sequenz: AA 166-406

Produktmerkmale: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 33-36 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM MOPS, 100 mM NaCl, pH 7.2

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Antigendetails

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Andere Bezeichnung: Angiopoietin-Like 4 (ANGPTL4 Produkte)

Synonyme: ANGPTL2 Protein, ARP4 Protein, FIAF Protein, HFARP Protein, NL2 Protein, PGAR Protein, pp1158 Protein, Arp4 Protein, Bk89 Protein, Fiaf Protein, Hfarp Protein, Ng27 Protein, Pgar Protein, Pgarg Protein, Pp1158 Protein, ANGPTL4 Protein, fiaf Protein, im:7144703 Protein, si:rp71-39b20.7 Protein, angiopoietin like 4 Protein, angiopoietin-like 4 Protein, ANGPTL4 Protein, Angptl4 Protein, angptl4 Protein

Hintergrund: Angiopoietin-related protein 4 (ANGPTL4) is also known as Hepatic fibrinogen / angiopoietin - related protein (HFARP), ARP4, PGAR. ANGPTL4 contains one fibrinogen C-terminal domain. ANGPTL4 is a homooligomer , and the homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix. ANGPTL4 may act as a regulator of angiogenesis and modulate tumorigenesis. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action.

Molekulargewicht: 27.9 kDa

NCBI Accession: NP_647475

Pathways: Regulation of Lipid Metabolism by PPARalpha