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ANGPTL4 Protein (AA 166-406, Fibrinogen-like Domain) (DYKDDDDK Tag)

ANGPTL4 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % (SDS-PAGE) SDS
Produktnummer ABIN1344308
  • Target Alle ANGPTL4 Proteine anzeigen
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Fibrinogen-like Domain, AA 166-406
    Spezies
    • 10
    • 8
    • 3
    • 3
    • 3
    • 1
    Human
    Quelle
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ANGPTL4 Protein ist gelabelt mit DYKDDDDK Tag.
    Applikation
    SDS-PAGE (SDS)
    Kreuzreaktivität
    Human
    Produktmerkmale
    Fibrinogen-like domain of human ANGPTL4 (aa 166-406) is fused at the N-terminus to a FLAG®-tag.
    Reinheit
    >90 % (SDS-PAGE)
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product ANGPTL4 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    0.2μm-filtered solution in PBS.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Working aliquots are stable for up to 3 months when stored at -20°C.
    Haltbarkeit
    3 months
  • Target
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Andere Bezeichnung
    ANGPTL4 (ANGPTL4 Produkte)
    Synonyme
    ANGPTL2 Protein, ARP4 Protein, FIAF Protein, HFARP Protein, NL2 Protein, PGAR Protein, pp1158 Protein, Arp4 Protein, Bk89 Protein, Fiaf Protein, Hfarp Protein, Ng27 Protein, Pgar Protein, Pgarg Protein, Pp1158 Protein, ANGPTL4 Protein, fiaf Protein, im:7144703 Protein, si:rp71-39b20.7 Protein, angiopoietin like 4 Protein, angiopoietin-like 4 Protein, ANGPTL4 Protein, Angptl4 Protein, angptl4 Protein
    Hintergrund
    ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
    Molekulargewicht
    ~35kDa (SDS-PAGE)
    UniProt
    Q9BY76
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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