Thrombopoietin Protein (THPO) (AA 22-356)

Produktnummer ABIN2018397

Recombinant Thrombopoietin-Protein exprimiert in CHO Cells.

Kurzübersicht für Thrombopoietin Protein (THPO) (AA 22-356) (ABIN2018397)

Target: Thrombopoietin (THPO)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: CHO Cells

Reinheit: > 95 % as analyzed by SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 22-356

Produktmerkmale: ED50 < 2 ng /mL, measured in a proliferation assay using MO7e cells.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL..

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant murine Thrombopoietin (TPO) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Thrombopoietin (TPO) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Thrombopoietin (THPO)

Andere Bezeichnung: Thrombopoietin (TPO)

Hintergrund: Thrombopoietin (TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.
Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

Molekulargewicht: 30-80 kDa, observed by reducing SDS-PAGE.

UniProt: P40226

Pathways: JAK-STAT Signalweg, Hormone Activity